Photoredox/palladium co-catalyzed propargylic benzylation with internal propargylic carbonates. Issue 85 (28th September 2020)

• Record Type: Journal Article
• Authors: Zhou, Zhao-Zhao; Jiao, Rui-Qiang; Yang, Ke; Chen, Xi-Meng; Liang, Yong-Min
• Is Part Of: Chemical communications. Volume 56:Issue 85(2020)
• Page Start: 12957
• Page End: 12960
• Publication Date: 2020-09-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc04986g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The developed photo/palladium dual catalytic system provided a novel route to internal propargylic benzylation products. A radical coupling mechanism between the propargylic radical and benzyl radical was proposed. Abstract : Herein, a highly regioselective propargylic benzylation with propargylic carbonates and benzyl 1, 4-dihydropyridine derivatives was developed via a photoredox/palladium dual-catalyzed process, which represents a novel catalytic model for non-terminal propargylic functionalization. The reaction showed excellent regioselectivity and functional group compatibility. A radical coupling mechanism between the propargylic radical and benzyl radical was proposed.