Photoredox/palladium co-catalyzed propargylic benzylation with internal propargylic carbonates. Issue 85 (28th September 2020) - Zhou, Zhao-Zhao
Abstract : The developed photo/palladium dual catalytic system provided a novel route to internal propargylic benzylation products. A radical coupling mechanism between the propargylic radical and benzyl radical was proposed. Abstract : Herein, a highly regioselective propargylic benzylation with propargylic carbonates and benzyl 1, 4-dihydropyridine derivatives was developed via a photoredox/palladium dual-catalyzed process, which represents a novel catalytic model for non-terminal propargylic functionalization. The reaction showed excellent regioselectivity and functional group compatibility. A radical coupling mechanism between the propargylic radical and benzyl radical was proposed.