The effects of chard on brain damage in valproic acid‐induced toxicity. Issue 10 (4th August 2020)

• Record Type: Journal Article
• Authors: Tunali, Sevim; Cimen, Esra Sule; Yanardag, Refiye
• Is Part Of: Journal of food biochemistry. Volume 44:Issue 10(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-08-04
• Subjects: brain -- chard -- enzymes -- oxidative stress -- toxicity -- valproic acid; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Biochemistry -- Periodicals; 664.024
• DOI: 10.1111/jfbc.13382
• Languages: English
• ISSNs: 0145-8884

Abstract

Abstract: Valproic acid (VPA; 2‐propyl valeric acid) is a potent drug widely used in treating anxiety disorders, migraine as well as epileptic diseases. In the ongoing study chard protective effect was investigated, on the damaged VPA rat brain. Sprague Dawley rats (females) were grouped as follows: control, VPA (500 mg kg −1 day −1 VPA intraperitoneal), chard (100 mg/kg day chard extract by gavage), VPA + chard (500 mg kg −1 day −1 VPA + 100 mg kg −1 day −1 chard extract). Aqueous chard leaves extract was given 1 hr before apply VPA for a period of 7 days. Lipid peroxidation, advanced oxidation protein products and protein carbonyl content, and superoxide dismutase, glutathione peroxidase, glutathione‐S‐transferase, and glutathione reductase activities increased in the VPA group. Reduced glutathione levels, paraoxanase, and acetylcholinesterase activities were significantly diminished in the VPA animals. Chard extract application curatively reverted the studied biochemical parameters. The results obtained, it has been found the chard has a protective and antioxidant effect on brain damage induced by VPA. Practical applications: Valproic acid is a comparably safe pharmaceutical agent, but it can cause severe adverse effects on biological metabolism when it is used in high amount. There are not many studies declared that VPA stimulate the generation of ROS, which is liable for the life‐threatening adverse effects of VPA therapy including hepatotoxicity neurotoxicity and teratogenicity. Chard is a plant which has antimicrobial, antibacterial, antiinflammatory, antioxidant, antitumor, antiacetylcholinesterase activities, and hepatoprotective effects. In the current study we examined the protection of the VPA damaged rat brain by chard. Abstract : This research shed new light upon these investigations and suggest that the oxidative damage caused by VPA disrupt the antioxidant status of the neuronal tissue and afterwards may cause substantial brain cell death. Treatment with chard, which has a rich content of flavonoids, saponins, pectins, vitamins and minerals, has a healing effects against oxidative damage caused by VPA in brain toxicity. This effect may be is due to its antioxidant properties.