3-Aminooxetanes: versatile 1, 3-amphoteric molecules for intermolecular annulation reactions. Issue 36 (8th September 2020)

• Record Type: Journal Article
• Authors: Lai, Zengwei; Zhang, Renwei; Feng, Qiang; Sun, Jianwei
• Is Part Of: Chemical science. Volume 11:Issue 36(2020)
• Page Start: 9945
• Page End: 9949
• Publication Date: 2020-09-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d0sc04254d
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : Despite the versatility of amphoteric molecules, stable and easily accessible ones are still limitedly known. Abstract : Despite the versatility of amphoteric molecules, stable and easily accessible ones are still limitedly known. As a result, the discovery of new amphoteric reactivity remains highly desirable. Herein we introduce 3-aminooxetanes as a new family of stable and readily available 1, 3-amphoteric molecules and systematically demonstrated their amphoteric reactivity toward polarized π-systems in a diverse range of intermolecular [3 + 2] annulations. These reactions not only enrich the reactivity of oxetanes, but also provide convergent access to valuable heterocycles.