3-Aminooxetanes: versatile 1, 3-amphoteric molecules for intermolecular annulation reactions. Issue 36 (8th September 2020) - Lai, Zengwei
Abstract : Despite the versatility of amphoteric molecules, stable and easily accessible ones are still limitedly known. Abstract : Despite the versatility of amphoteric molecules, stable and easily accessible ones are still limitedly known. As a result, the discovery of new amphoteric reactivity remains highly desirable. Herein we introduce 3-aminooxetanes as a new family of stable and readily available 1, 3-amphoteric molecules and systematically demonstrated their amphoteric reactivity toward polarized π-systems in a diverse range of intermolecular [3 + 2] annulations. These reactions not only enrich the reactivity of oxetanes, but also provide convergent access to valuable heterocycles.