Modular Manufacturing Platform for Continuous Synthesis and Analysis of Versatile Nanomaterials. Issue 10 (17th July 2019)

• Record Type: Journal Article
• Authors: von Bomhard, Sibylle; Schramm, Jonas; Bleul, Regina; Thiermann, Raphael; Höbel, Peter; Krtschil, Ulrich; Löb, Patrick; Maskos, Michael
• Other Names: Dittmeyer Roland guestEditor.
• Is Part Of: Chemical engineering & technology. Volume 42:Issue 10(2019)
• Page Start: 2085
• Page End: 2094
• Publication Date: 2019-07-17
• Subjects: Downstream processing -- Dynamic light scattering -- Flow chemistry -- Microreaction technology -- Nanoparticles; Chemical engineering -- Periodicals; Chemical processes -- Periodicals; 660.05
• DOI: 10.1002/ceat.201900115
• Languages: English
• ISSNs: 0930-7516

Abstract

Abstract: Nanoparticular materials have a great potential in various fields including technical and biomedical applications; to meet the specific requirements, a good control over the particle characteristics is mandatory. Addressing this, a modular system for the automated and continuous synthesis, workup, and analysis of a broad range of nanoparticles was developed. Application examples of inorganic (silica) and organic (polymersomes, niosomes) nanoparticles demonstrate the versatility of the production platform. Modules for downstream processing via a falling‐film microreactor or tangential flow filtration are presented. The hydrodynamic size as a key parameter is acquired in real time, with an inline dynamic light scattering device. All modules are controlled and operated by a process control system. Abstract : Flow chemistry has proved to be a suitable tool for the production of a variety of nanoparticles. However, getting a ready‐to‐use, purified and well‐defined product usually involves a large amount of manual labor. A modular system was developed and tested for different examples to explore the integration of continuous downstream processing and analytics into a fully continuous production setup.