Modular Manufacturing Platform for Continuous Synthesis and Analysis of Versatile Nanomaterials. Issue 10 (17th July 2019) - von Bomhard, Sibylle
Abstract: Nanoparticular materials have a great potential in various fields including technical and biomedical applications; to meet the specific requirements, a good control over the particle characteristics is mandatory. Addressing this, a modular system for the automated and continuous synthesis, workup, and analysis of a broad range of nanoparticles was developed. Application examples of inorganic (silica) and organic (polymersomes, niosomes) nanoparticles demonstrate the versatility of the production platform. Modules for downstream processing via a falling‐film microreactor or tangential flow filtration are presented. The hydrodynamic size as a key parameter is acquired in real time, with an inline dynamic light scattering device. All modules are controlled and operated by a process control system. Abstract : Flow chemistry has proved to be a suitable tool for the production of a variety of nanoparticles. However, getting a ready‐to‐use, purified and well‐defined product usually involves a large amount of manual labor. A modular system was developed and tested for different examples to explore the integration of continuous downstream processing and analytics into a fully continuous production setup.