Intestinal absorption of small peptides: a review. (29th November 2018)

• Record Type: Journal Article
• Authors: Shen, Weilin; Matsui, Toshiro
• Is Part Of: International journal of food science & technology. Volume 54:Number 6(2019)
• Page Start: 1942
• Page End: 1948
• Publication Date: 2018-11-29
• Subjects: Absorption -- intestinal membrane -- PepT1 -- Peptide; Food industry and trade -- Periodicals; 664
• DOI: 10.1111/ijfs.14048
• Languages: English
• ISSNs: 0950-5423

Abstract

Summary: Peptides display diverse structural features because of their varied amino acid compositions. The structural diversity often imparts them complex physiological functions, or possible health‐beneficial effects. Some small peptides (di‐/tripeptides) exert preventive effects against conditions such as hypertension, hypercholesterolaemia and atherosclerosis. Despite their health benefits, a limited understanding of peptide absorption may hinder their extensive application. Therefore, this review briefly introduces the in vitro and in vivo findings on the intestinal absorption of small peptides and potential factors affecting their absorption. Abstract : Factors affecting the absorption of small peptides. Food and non‐food factors could affect the absorption of small peptides potentially via (1) competitive inhibition of PepT1, (2) transcriptional regulation of PepT1 and (3) maintenance of the proton gradient (a driving force for PepT1‐mediated transport).