Thiocladospolides F-J, antibacterial sulfur containing 12-membered macrolides from the mangrove endophytic fungus Cladosporium oxysporum HDN13-314. (October 2020)

• Record Type: Journal Article
• Authors: Wang, Wenxue; Feng, Huimin; Sun, Chunxiao; Che, Qian; Zhang, Guojian; Zhu, Tianjiao; Li, Dehai
• Is Part Of: Phytochemistry. Volume 178(2020)
• Publication Date: 2020-10
• Subjects: Avicennia marina (Forssk.) vierh. -- Cladosporium oxysporum -- Mangrove endophytic fungus -- Macrolide -- Thiocladospolide; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2020.112462
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Five undescribed 12-membered macrolides containing thioethers, thiocladospolides F-J, together with the known biogenetic related analogues, were isolated from a mangrove-derived endophytic fungus Cladosporium oxysporum . The absolute configuration of thiocladospolide F was deduced by single-crystal X-ray diffraction, and those of thiocladospolides G-J were determined based on specific optical rotation and electronic circular dichroism (ECD) data, as well as the biogenetic considerations. Thiocladospolide G display the best antimicrobial activity against the aquatic pathogen Edwardsiella tarda with minimal inhibit concentration (MIC) value of 4 μ g/mL. Graphical abstract: Image 1 Highlights: Five undescribed 12-membered macrolides were isolated from Cladosporium oxysporum. Thiocladospolide F showed the first single crystal of 12-membered macrolide dimer. Thiocladospolide G revealed antimicrobial activity against Edwardsiella tarda.