Thiocladospolides F-J, antibacterial sulfur containing 12-membered macrolides from the mangrove endophytic fungus Cladosporium oxysporum HDN13-314. (October 2020) - Wang, Wenxue
Abstract: Five undescribed 12-membered macrolides containing thioethers, thiocladospolides F-J, together with the known biogenetic related analogues, were isolated from a mangrove-derived endophytic fungus Cladosporium oxysporum . The absolute configuration of thiocladospolide F was deduced by single-crystal X-ray diffraction, and those of thiocladospolides G-J were determined based on specific optical rotation and electronic circular dichroism (ECD) data, as well as the biogenetic considerations. Thiocladospolide G display the best antimicrobial activity against the aquatic pathogen Edwardsiella tarda with minimal inhibit concentration (MIC) value of 4 μ g/mL. Graphical abstract: Image 1 Highlights: Five undescribed 12-membered macrolides were isolated from Cladosporium oxysporum. Thiocladospolide F showed the first single crystal of 12-membered macrolide dimer. Thiocladospolide G revealed antimicrobial activity against Edwardsiella tarda.