Effects of probiotic therapy on cardio-metabolic parameters and autonomic modulation in hypertensive women: a randomized, triple-blind, placebo-controlled trial. Issue 8 (5th August 2020)

• Record Type: Journal Article
• Authors: Romão da Silva, Larissa de Fátima; de Oliveira, Yohanna; de Souza, Evandro Leite; de Luna Freire, Micaelle Oliveira; Braga, Valdir de Andrade; Magnani, Marciane; de Brito Alves, José Luiz
• Is Part Of: Food & function. Volume 11:Issue 8(2020)
• Page Start: 7152
• Page End: 7163
• Publication Date: 2020-08-05
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/d0fo01661f
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : We assessed the effects of probiotic therapy for 8 weeks on cardiometabolic variables and autonomic function in women medically diagnosed with arterial hypertension. Abstract : Background and aims : We assessed the effects of probiotic therapy for 8 weeks on cardiometabolic variables and autonomic function in women medically diagnosed with arterial hypertension. Methods and results : Forty women with arterial hypertension, 20–50 years, were assigned to two groups in this randomized, triple-blind, placebo-controlled clinical trial. Patients in the probiotic group received a daily sachet containing Lactobacillus para casei LPC-37, Lactobacillus rhamnosus HN001, Lactobacillus acidophilus NCFM, and Bifidobacterium lactis HN019 (10 9 CFU of each strain) for 8 weeks. Patients in the placebo group received identical sachets with polydextrose (1 g day −1, for 8 weeks). Anthropometric, BP, electrocardiogram, biochemical measurements, fecal microbiota composition, and glucose hydrogen breath test were assessed at baseline and after 8 weeks intervention. Anthropometric variables (weight, BMI, and waist circumference) were similar between the two groups ( p > 0.05). Probiotic supplementation significantly reduced fasting glucose (change −10.3 mg dL −1, p < 0.05) and cholesterol levels (change −23.6 mg dL −1, p < 0.05), and increased the HDL-cholesterol (change 6.5 mg dL −1, p < 0.05) compared with the baseline condition. Probiotic supplementation lowered, although without statistical significance, systolic BP by about 5 mmHg and diastolic BP by about 2 mmHg in hypertensive women. Lastly, probiotic administration reduced the low frequency (LF) oscillation and LF/high frequency (HF) ratio ( p < 0.05) in the frequency domain of heart rate variability, suggesting an improvement in autonomic modulation. Conclusion : Probiotic therapy for 8 weeks reduced fasting glucose levels, and improved the lipid profile and autonomic modulation in hypertensive women.