Nickel(ii)-catalyzed asymmetric thio-Claisen rearrangement of α-diazo pyrazoleamides with thioindoles. Issue 69 (29th July 2020)

• Record Type: Journal Article
• Authors: Yang, Wei; Lin, Xiaobin; Zhang, Yongyan; Cao, Weidi; Liu, Xiaohua; Feng, Xiaoming
• Is Part Of: Chemical communications. Volume 56:Issue 69(2020)
• Page Start: 10002
• Page End: 10005
• Publication Date: 2020-07-29
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc04590j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A chiral Ni(ii ) complex catalyzed enantioselective thio-Claisen rearrangement of α-diazo pyrazoleamides with thioindoles. Abstract : A nickel(ii ) catalyzed enantioselective thio-Claisen rearrangement of α-diazo pyrazoleamides with thioindoles was realized with modified chiral N, N ′-dioxide ligands, affording a variety of C3-substituted indole derivatives in high yields (up to 95%) with excellent enantioselectivities (up to 96% ee) under mild reaction conditions. A possible transition state model was proposed based on previous reports and the X-ray crystal structure of the catalyst.