Nickel(ii)-catalyzed asymmetric thio-Claisen rearrangement of α-diazo pyrazoleamides with thioindoles. Issue 69 (29th July 2020) - Yang, Wei
Abstract : A chiral Ni(ii ) complex catalyzed enantioselective thio-Claisen rearrangement of α-diazo pyrazoleamides with thioindoles. Abstract : A nickel(ii ) catalyzed enantioselective thio-Claisen rearrangement of α-diazo pyrazoleamides with thioindoles was realized with modified chiral N, N ′-dioxide ligands, affording a variety of C3-substituted indole derivatives in high yields (up to 95%) with excellent enantioselectivities (up to 96% ee) under mild reaction conditions. A possible transition state model was proposed based on previous reports and the X-ray crystal structure of the catalyst.