Effects of a Cumulative, Suboptimal Supply of Multiple Trace Elements in Mice: Trace Element Status, Genomic Stability, Inflammation, and Epigenetics. Issue 16 (16th July 2020)

• Record Type: Journal Article
• Authors: Finke, Hannah; Winkelbeiner, Nicola; Lossow, Kristina; Hertel, Barbara; Wandt, Viktoria K.; Schwarz, Maria; Pohl, Gabriele; Kopp, Johannes F.; Ebert, Franziska; Kipp, Anna P.; Schwerdtle, Tanja
• Is Part Of: Molecular nutrition & food research. Volume 64:Issue 16(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-16
• Subjects: DNA (hydroxy)methylation -- genomic stability -- health parameters of mice -- trace element biomarkers -- trace element interactions; Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.202000325
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract: Scope: Trace element (TE) deficiencies often occur accumulated, as nutritional intake is inadequate for several TEs, concurrently. Therefore, the impact of a suboptimal supply of iron, zinc, copper, iodine, and selenium on the TE status, health parameters, epigenetics, and genomic stability in mice are studied. Methods and results: Male mice receive reduced or adequate amounts of TEs for 9 weeks. The TE status is analyzed mass‐spectrometrically in serum and different tissues. Furthermore, gene and protein expression of TE biomarkers are assessed with focus on liver. Iron concentrations are most sensitive toward a reduced supply indicated by increased serum transferrin levels and altered hepatic expression of iron‐related genes. Reduced TE supply results in smaller weight gain but higher spleen and heart weights. Additionally, inflammatory mediators in serum and liver are increased together with hepatic genomic instability. However, global DNA (hydroxy)methylation is unaffected by the TE modulation. Conclusion: Despite homeostatic regulation of most TEs in response to a low intake, this condition still has substantial effects on health parameters. It appears that the liver and immune system react particularly sensitive toward changes in TE intake. The reduced Fe status might be the primary driver for the observed effects. Abstract : This study investigates the impact of a reduced trace element supply of iron, zinc, copper, iodine, selenium, and manganese on the trace element status, health parameters, epigenetics, and genomic stability in mice. The iron status and physical characteristics of the mice are distinctly affected and accompanied by mild inflammation and increased genomic instability, while global DNA (hydroxy)methylation is unaffected.