A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery. Issue 20 (24th March 2020)

• Record Type: Journal Article
• Authors: Zhao, Deyao; Yang, Ge; Liu, Qing; Liu, Wenjing; Weng, Yuhua; Zhao, Yi; Qu, Feng; Li, Lele; Huang, Yuanyu
• Is Part Of: Nanoscale. Volume 12:Issue 20(2020)
• Page Start: 10939
• Page End: 10943
• Publication Date: 2020-03-24
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d0nr00301h
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Spatiotemporal controllable siRNA delivery and gene modulation by light-triggerable aptamer nanoswitcher was reported in this study, which achieved on-demand siRNA internalization by cancer cells at desired site and time in vitro and in vivo . Abstract : A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo .