A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery. Issue 20 (24th March 2020) - Zhao, Deyao
Abstract : Spatiotemporal controllable siRNA delivery and gene modulation by light-triggerable aptamer nanoswitcher was reported in this study, which achieved on-demand siRNA internalization by cancer cells at desired site and time in vitro and in vivo . Abstract : A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo .