An overview on the biosynthesis and metabolic regulation of monacolin K/lovastatin. Issue 7 (18th June 2020)

• Record Type: Journal Article
• Authors: Zhang, Yaru; Chen, Zhiting; Wen, Qinyou; Xiong, Zixiao; Cao, Xiaohua; Zheng, Zhenghuai; Zhang, Yangxin; Huang, Zhiwei
• Is Part Of: Food & function. Volume 11:Issue 7(2020)
• Page Start: 5738
• Page End: 5748
• Publication Date: 2020-06-18
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/d0fo00691b
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : Lovastatin/monacolin K (MK) is used as a lipid lowering drug, due to its effective hypercholesterolemic properties, comparable to synthetic statins. Abstract : Lovastatin/monacolin K (MK) is used as a lipid lowering drug, due to its effective hypercholesterolemic properties, comparable to synthetic statins. Lovastatin's biosynthetic pathway and gene cluster composition have been studied in depth in Aspergillus terreus . Evidence shows that the MK biosynthetic pathway and gene cluster in Monascus sp. are similar to those of lovastatin in A. terreus . Currently, research efforts have been focusing on the metabolic regulation of MK/lovastatin synthesis, and the evidence shows that a combination of extracellular and intracellular factors is essential for proper MK/lovastatin metabolism. Here, we comprehensively review the research progress on MK/lovastatin biosynthetic pathways, its synthetic precursors and inducing substances and metabolic regulation, with a view to providing reference for future research on fungal metabolism regulation and metabolic engineering for MK/lovastatin production.