Anti-Alzheimer's disease activity of secondary metabolites from Xanthoceras sorbifolia Bunge. Issue 3 (6th March 2020)

• Record Type: Journal Article
• Authors: Li, Wei; Lu, Qiuli; Li, Xiang; Liu, Hongcui; Sun, Liangdi; Lu, Xiao; Zhao, Yuqing; Liu, Peng
• Is Part Of: Food & function. Volume 11:Issue 3(2020)
• Page Start: 2067
• Page End: 2079
• Publication Date: 2020-03-06
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/c9fo01138b
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : Xanthoceras sorbifolia Bunge is an edible oil tree species peculiar to China and it has long been used as a traditional medicine for enuresis in children. In this paper, X. sorbifolia was found to have significant anti-Alzheimer's activity. Abstract : Xanthoceras sorbifolia Bunge is an edible oil tree species peculiar to China and it has long been used as a traditional medicine for enuresis in children. In this study, we investigated the active components in X. sorbifolia and eight barrigenol-type triterpenoids were isolated and identified. All the isolated compounds were tested first for H2 O2 -induced oxidative stress on human SH-SY5Y cells. Then Y-maze, Morris water maze, novel object recognition and passive avoidance tests were conducted to evaluate the improved effect of selected compounds with neuroprotective activity on ICV Aβ1–42 mice. Among all the tested compounds, XS-8 exhibited significant protective effects against learning and memory impairments induced by ICV-Aβ1–42 . The XS-8 treatment significantly altered Aβ-induced hippocampal oxidative defense (increased MDA, nitrite and decreased SOD, glutathione) and pro-inflammatory levels (increased IL-1β and IL-18). The present study strongly suggests that X. sorbifolia is a promising plant resource for AD use and other neurodegenerative diseases.