Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres. Issue 61 (17th July 2020)

• Record Type: Journal Article
• Authors: Zhu, Min; Yu, Yanyan; Zhu, Junfeng; Zhou, Yao; Su, Gaoxing; Zhu, Hongyan; Chen, Yong; Liu, Mingkai
• Is Part Of: Chemical communications. Volume 56:Issue 61(2020)
• Page Start: 8599
• Page End: 8602
• Publication Date: 2020-07-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc03425h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide acanthospheres are proposed for the discrimination of single nucleotide variants (SNVs) with significantly improved sensitivity and specificity. Abstract : Toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide (MoS2 ) acanthospheres were proposed for the discrimination of single nucleotide variants (SNVs). We rationally optimized the probe by making a trade-off between the discrimination factor (DF) and hybridization ratio ( χ ). The TESNA platform can distinguish SNVs with significantly improved sensitivity and specificity.