Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres. Issue 61 (17th July 2020) - Zhu, Min
Abstract : Toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide acanthospheres are proposed for the discrimination of single nucleotide variants (SNVs) with significantly improved sensitivity and specificity. Abstract : Toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide (MoS2 ) acanthospheres were proposed for the discrimination of single nucleotide variants (SNVs). We rationally optimized the probe by making a trade-off between the discrimination factor (DF) and hybridization ratio ( χ ). The TESNA platform can distinguish SNVs with significantly improved sensitivity and specificity.