Integrity of Amygdala Subregion-Based Functional Networks and Emotional Lability in Drug-Naïve Boys With ADHD. Issue 12 (October 2020)

• Record Type: Journal Article
• Authors: Yu, Xiaoyan; Liu, Lu; Chen, Wai; Cao, Qingjiu; Zepf, Florian Daniel; Ji, Gongjun; Wu, Zhaomin; An, Li; Wang, Peng; Qian, Qiujin; Zang, Yufeng; Sun, Li; Wang, Yufeng
• Is Part Of: Journal of attention disorders. Volume 24:Issue 12(2020)
• Page Start: 1661
• Page End: 1673
• Publication Date: 2020-10
• Subjects: ADHD -- amygdala subregions -- resting-state functional connectivity -- emotional lability -- dorsal prefrontal cortex; Attention-deficit hyperactivity disorder -- Periodicals; Attention -- Periodicals; 616.8589
• DOI: 10.1177/1087054716661419
• Languages: English
• ISSNs: 1087-0547

Abstract

Objective: This study evaluated the functional networks of amygdala subregions (basolateral [BLA], centromedial [CMA], and superficial amygdala [SFA]) in ADHD and their association with emotional lability (EL) symptoms.Method: Resting-state functional connectivity (RSFC) of amygdala subregions and their correlations with EL scores were evaluated in 35 drug-naïve boys with ADHD and 30 age-matched healthy controls (HC).Results: Compared with HC, altered RSFC were detected differently for each amygdala subregion in ADHD: altered RSFC of BLA with the thalamus and vermis; aberrant RSFC of CMA with the superior temporal gyrus/pole and insula, precuneus and cerebellum; reduced RSFC of SFA with dorsal frontoparietal cortices. Within ADHD, higher EL scores were associated with reduced negative RSFC of SFA with the dorsolateral prefrontal cortex and inferior parietal lobe.Conclusion: Diffuse alterations of amygdala subregion-based networks are associated with ADHD, and the weaker SFA–frontoparietal networks might be involved in the hypothesized top–down effortful regulation of emotion.