In Utero One‐Carbon Metabolism Interplay and Metabolic Syndrome in Cardiovascular Disease Risk Reduction. Issue 4 (26th August 2019)

• Record Type: Journal Article
• Authors: Mabasa, Lawrence; Samodien, Ebrahim; Sangweni, Nonhlakanipho F.; Pheiffer, Carmen; Louw, Johan; Johnson, Rabia
• Is Part Of: Molecular nutrition & food research. Volume 64:Issue 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-08-26
• Subjects: cardiovascular disease -- DNA methylation -- fetal programming -- maternal one‐carbon metabolism -- non‐alcoholic fatty liver disease; Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201900377
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract: The maternal obesogenic environment plays a role in programing the susceptibility of the fetus to postnatal non‐alcoholic fatty liver disease (NAFLD), a risk factor for cardiovascular disease (CVD). NAFLD is a multisystem disease that is characterized by hepatic fat accumulation due in part to dysregulated energy metabolism network through epigenetic mechanisms such as DNA methylation. DNA methylation affects fetal programing and disease risk via regulation of gene transcription; it is affected by methyl donor nutrients such as vitamin B12, methionine, folic acid, vitamin B6, and choline. Although several studies have documented the role of several maternal methyl donor nutrients on obesity‐induced NAFLD in offspring, currently, data are lacking on its impact on CVD risk as an endpoint. The aim of this paper is to use current knowledge to construct a postulation for the potential role of a comprehensive gestational methyl donor nutrients supplementary approach on the susceptibility of offspring to developing metabolic‐syndrome‐related cardiovascular complications. Abstract : The global prevalence of cardiovascular disease has dramatically increased in the last decades due to a rise in obesity cases. The aim of this review is to use current knowledge to offer a postulation for the role of maternal calorie‐dense foods in regulation of one‐carbon metabolism, a process known to affect fetal gene signatures and postnatal cardiometabolic outcomes.