Trifluoromethylation of Alkyl Radicals: Breakthrough and Challenges†. Issue 7 (12th May 2020)

• Record Type: Journal Article
• Authors: Zhu, Lin; Fang, Yewen; Li, Chaozhong
• Is Part Of: Chinese journal of chemistry. Volume 38:Issue 7(2020)
• Page Start: 787
• Page End: 789
• Publication Date: 2020-05-12
• Subjects: Radical reactions -- Copper -- Trifluoromethylation -- Synthetic methods -- Mechanism; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.202000095
• Languages: English
• ISSNs: 1001-604X

Abstract

Abstract : Trifluoromethylation of alkyl radicals is emerging as a powerful tool for C(sp 3 )–CF3 bond formations. Based on the hypothesis of CF3 group transfer from Cu(II)–CF3 to alkyl radicals, a number of trifluoromethylation reactions have been developed, including trifluoromethylation of alkyl halides, decarboxylative trifluoromethylation of aliphatic carboxylic acids, C(sp 3 )–H trifluoromethylation, amino‐ and carbo‐trifluoromethylation of alkenes, etc . Challenges in this intriguing field are also discussed. Abstract : The recent advances in copper‐promoted/catalyzed trifluoromethylation of alkyl radicals are briefly summarized and challenges in this intriguing new field are discussed.