Trifluoromethylation of Alkyl Radicals: Breakthrough and Challenges†. Issue 7 (12th May 2020) - Zhu, Lin
Abstract : Trifluoromethylation of alkyl radicals is emerging as a powerful tool for C(sp 3 )–CF3 bond formations. Based on the hypothesis of CF3 group transfer from Cu(II)–CF3 to alkyl radicals, a number of trifluoromethylation reactions have been developed, including trifluoromethylation of alkyl halides, decarboxylative trifluoromethylation of aliphatic carboxylic acids, C(sp 3 )–H trifluoromethylation, amino‐ and carbo‐trifluoromethylation of alkenes, etc . Challenges in this intriguing field are also discussed. Abstract : The recent advances in copper‐promoted/catalyzed trifluoromethylation of alkyl radicals are briefly summarized and challenges in this intriguing new field are discussed.