The GRIN2B and GRIN2A Gene Variants Are Associated With Continuous Performance Test Variables in ADHD. Issue 11 (September 2020)

• Record Type: Journal Article
• Authors: Kim, Johanna Inhyang; Kim, Jae-Won; Park, Subin; Hong, Soon-Beom; Lee, Dong Soo; Paek, Sun Ha; Han, Doug Hyun; Cheong, Jae Hoon; Kim, Bung-Nyun
• Is Part Of: Journal of attention disorders. Volume 24:Issue 11(2020)
• Page Start: 1538
• Page End: 1546
• Publication Date: 2020-09
• Subjects: attention-deficit/hyperactivity disorder -- genetics -- neurocognitive measures; Attention-deficit hyperactivity disorder -- Periodicals; Attention -- Periodicals; 616.8589
• DOI: 10.1177/1087054716649665
• Languages: English
• ISSNs: 1087-0547

Abstract

Objective: To examine the association between variants of N-methyl-D-aspartate (NMDA) receptor subunit-encoding genes ( GRIN2A and GRIN2B ) and continuous performance test (CPT) variables in ADHD and healthy controls.Method: In all, 253 ADHD patients and 98 controls were recruited. The diagnosis, genotype, and diagnosis–genotype interaction effects for the CPT variables were examined.Results: Significant diagnosis effects were detected for all CPT variables. There were significant genotype and interaction effects on response time variability (RTV) by the GRIN2B variant. The C/C subgroup had higher RTV than the C/T + T/T subgroup in ADHD, but not in controls. There were significant genotype effects on omission errors by the GRIN2A variant. The G/G subgroup had more omission errors than the G/A + A/A subgroup in ADHD patients, but not in controls.Conclusion: These results suggest that the genetic variants of GRIN2B and GRIN2A confer an increased susceptibility to attentional impairment in ADHD patients.