Receiver Operating Characteristic Curve Analysis of Screening Tools for Bipolar Disorder Comorbid With ADHD in Schoolchildren. Issue 10 (August 2020)

• Record Type: Journal Article
• Authors: Cordeiro, Mara L.; Farias, Antonio C.; Whybrow, Peter C.; Felden, Erico P. G.; Cunha, Alexandre; da Veiga, Vilmar; Benko, Cássia R.; McCracken, James T.
• Is Part Of: Journal of attention disorders. Volume 24:Issue 10(2020)
• Page Start: 1403
• Page End: 1412
• Publication Date: 2020-08
• Subjects: ADHD -- bipolar -- receiver operating characteristic -- diagnostic validity; Attention-deficit hyperactivity disorder -- Periodicals; Attention -- Periodicals; 616.8589
• DOI: 10.1177/1087054715620897
• Languages: English
• ISSNs: 1087-0547

Abstract

Objective: We compared Child Behavior Checklist (CBCL)-AAA (Attention Problems, Aggressive Behavior, and Anxious/Depressed) and Parent–Young Mania Rating Scale (P-YMRS) profiles in Brazilian children with ADHD, pediatric-onset bipolar disorder (PBD), and PBD + ADHD.Method: Following analyses of variance or Kruskal–Wallis tests with multiple-comparison Least Significant Difference (LSD) or Dunn's Tests, thresholds were determined by Mann–Whitney U Tests and receiver operating characteristic (ROC) plots.Results: Relative to ADHD, PBD and PBD + ADHD groups scored higher on the Anxious/Depressed, Thought Problems, Rule-Breaking, and Aggressive Behavior subscales and Conduct/Delinquency Diagnostic Scale of the CBCL; all three had similar attention problems. The PBD and PBD + ADHD groups scored higher than the ADHD and healthy control (HC) groups on all CBCL problem scales. The AAA-profile ROC had good diagnostic prediction of PBD + ADHD. PBD and PBD-ADHD were associated with (similarly) elevated P-YMRS scores.Conclusion: The CBCL-PBD and P-YMRS can be used to screen for manic behavior and assist in differential diagnosis.