25-Hydroxyvitamin D level, vitamin D intake, and risk of stroke: A dose–response meta-analysis. Issue 7 (July 2020)

• Record Type: Journal Article
• Authors: Shi, Han; Chen, Hanze; Zhang, Yun; Li, Jinwei; Fu, Kailei; Xue, Weishuang; Teng, Weiyu; Tian, Li
• Is Part Of: Clinical nutrition. Volume 39:Issue 7(2020)
• Page Start: 2025
• Page End: 2034
• Publication Date: 2020-07
• Subjects: Stroke -- Vitamin D -- Meta-analysis -- Cohort studies; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2019.08.029
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: A growing number of studies have shown that vitamin D are related to the risk of stroke, however, the dose–response association between vitamin D and the risk of stroke is still unclear. Accordingly, we conducted a dose–response meta-analysis to evaluate the relationships between 25-hydroxyvitamin D [25(OH)D] level, vitamin D intake, and the risk of stroke by summarizing cohort studies. Methods: PubMed, Embase, Cochrane and the Web of Science database were searched for related studies. Cohort studies examining the influence of 25(OH)D level and vitamin D intake on stroke risk were summarized. Dose–response relationships were determined using a random-effect model. Results: Twenty cohort studies involving 217, 235 participants were included. The pooled relative risk for the high-versus-low categories was 0.74 (95% CI: 0.66–0.83) for 25(OH)D level, and 0.75 (95% CI: 0.57–0.98) for vitamin D intake. In addition, there were non-linear relationships between 25(OH)D level, vitamin D intake, and stroke risk. The incidence of stroke was reduced to its lowest point, with a reduction of about 20%, when 25(OH)D level was about 50 nmol/L or vitamin D intake was about 12 μg/day. Conclusion: 25(OH)D level and vitamin D intake were both inversely related to stroke risk, with a non-linear dose–response relationship.