Core-shell nanoparticles for co-encapsulation of coenzyme Q10 and piperine: Surface engineering of hydrogel shell around protein core. (June 2020)

• Record Type: Journal Article
• Authors: Chen, Shuai; Zhang, Yanhui; Qing, Jing; Han, Yahong; McClements, David Julian; Gao, Yanxiang
• Is Part Of: Food hydrocolloids. Volume 103(2020)
• Publication Date: 2020-06
• Subjects: Zein -- κ-Carrageenan -- Core-shell nanoparticles -- Coenzyme Q10 -- Piperine -- Physiochemical stability; Hydrocolloids -- Periodicals; Food additives -- Periodicals; Colloïdes -- Périodiques; Aliments -- Additifs -- Périodiques; Colloids; Food additives; Periodicals; Electronic journals; 664.06
• DOI: 10.1016/j.foodhyd.2020.105651
• Languages: English
• ISSNs: 0268-005X

Abstract

Abstract: In the present study, the fabrication and characterization of novel core-shell-type surface-engineered nanoparticles were reported for co-encapsulation of coenzyme Q10 and piperine, which were natural nutraceuticals with synergistic biological activities. Initially, nutraceutical-loaded zein nanoparticles were formed by antisolvent precipitation method. Then, κ -carrageenan was adsorbed to the surface of zein nanoparticles using electrostatic deposition. Finally, the κ -carrageenan layer was induced into a hydrogel shell by using K + as a cross-linking agent. At low K + levels (0–4 mmol/L), the relatively small spherical anionic nanoparticles were formed and were stable. However, at high K + levels (4–10 mmol/L), the nanoparticles formed were relatively large and tended to aggregate. A photodegradation result showed that the half-lives of coenzyme Q10 and piperine were increased by 3.0- and 1.8-fold, respectively, when encapsulated in the biopolymer nanoparticles compared to the free forms. Moreover, their retention rates were increased by 151% and 200% during thermal treatment, and 111% and 131% during a four-week storage, respectively. Besides, the release of the nutraceuticals from the biopolymer nanoparticles in a simulated gastrointestinal tract could be retarded by increasing the degree of interfacial cross-linking. In summary, the core-shell nanoparticles developed here are an effective approach for the co-delivery of synergistic nutraceuticals. Graphical abstract: Image 1 Highlights: Core-shell-type surface-engineered nanoparticles with a shell of hydrogel were fabricated. Microtopography and secondary structure of zein in the nanoparticles were changed. K + induced nanoparticles became better delivery vehicle of synergistic nutraceuticals. Coenzyme Q10 and piperine in nanoparticles exhibited better light and thermal stability. K + induced nanoparticles delayed the release of nutraceuticals during in vitro digestion.