Β-cyclodextrin- soy soluble polysaccharide based core-shell bionanocomposites hydrogel for vitamin E swelling controlled delivery. (July 2020)

• Record Type: Journal Article
• Authors: Eid, Mohamed; Sobhy, Remah; Zhou, Peiyuan; Wei, Xianling; Wu, Di; Li, Bin
• Is Part Of: Food hydrocolloids. Volume 104(2020)
• Publication Date: 2020-07
• Subjects: Hydrocolloids -- Periodicals; Food additives -- Periodicals; Colloïdes -- Périodiques; Aliments -- Additifs -- Périodiques; Colloids; Food additives; Periodicals; Electronic journals; 664.06
• DOI: 10.1016/j.foodhyd.2020.105751
• Languages: English
• ISSNs: 0268-005X

Abstract

Abstract: Hydrogel nanocomposites (HGNCs), with a hydrophobic inner hollows structure and a hydrophilic exterior, is often used to encapsulate the broadest range of guest molecules. Herein, we established a three-dimensional, nanocomposites, superabsorbent, malleable, and bioadhesive HGNCs via chemical crosslinker poly (ethylene glycol) diglycidyl ether (PEGDGE) to enhance the controlled release and bioavailability of Vitamin E (VE). β-cyclodextrin (β-CD) are integrated as multi-core units in the soy soluble polysaccharide (SSPS) polymer network in which the β-CD cavities act as carriers for (VE) by host-guest interaction. We have examined the detailed structures and morphology by FTIR, DSC, XRD, SEM, TEM, AFM, and CLSM. Overall, increasing the β-CD than SSPS in the reaction mixture (from 10 to 25%) led to enhance the crosslinking degree, improve the elastic behavior (G′>G″), increase the particle size (from 114.2 to 202.9 nm), and the hardness. Besides, decreasing the adhesiveness, pore size, and swelling. Our (HGNCs) did not rupture under compression up to 90% strain with (1.8 MPa) strength. The nanocomposites (1:1) exhibited less nanosized after pectinase and α-amylase hydrolysis (75 and 124 nm, respectively). Also, the (HGNCs) exhibited outstanding swelling-adsorption and sustained release (over 230 h) towards VE in vitro. It showed high encapsulation efficiency and loading capacity (79.10 and 16.04%, respectively). Additionally, the oral administration of VE-loaded HGNCs in rats resulted in a sustained increase of plasma VE levels over 12 h post-administration. The relative pharmacological bioavailability of VE was larger for VE-loaded HGNCs (reached to 7.5-fold increase) compared to free VE suspension. Keywords : Nanohydrogel; β-cyclodextrin; Soy soluble polysaccharide; Vitamin E; swelling; control release. Graphical abstract: Image 1 Highlights: β-CD and SSPS could spontaneously form HGNCs through one synthesis step. The HGNCs contained β-CD as multi-core and SSPS as shell. The hydrogel compositions were exhibited in spherical nanoparticles as nanonetwork. Increasing the β-CD than SSPS improved the crosslinking degree and hardness. The hydrogel has tunable swelling release property with VE in vitro and in vivo.