Concise review: Coarse cereals exert multiple beneficial effects on human health. (30th September 2020)

• Record Type: Journal Article
• Authors: Fu, Jia; Zhang, Yan; Hu, Yichen; Zhao, Gang; Tang, Yong; Zou, Liang
• Is Part Of: Food chemistry. Volume 325(2020)
• Publication Date: 2020-09-30
• Subjects: Coarse grains -- Cereals -- Probiotics -- Prebiotics -- Intestinal flora -- Cancer -- Cardiovascular disease -- Inflammation; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2020.126761
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Coarse cereals regulate intestinal flora structure. Coarse cereals prevent tumor by affecting cell cycle arrest and apoptosis. Coarse cereals protect cardiovascular system by blocking inflammatory signaling. Coarse cereals with advanced formulation development have prebiotics potential. Abstract: Coarse cereals (CC) refer to cereal grains except for rice and wheat which are highly-valued as functional foods with nutritional and pharmacological properties. Owing to their diverse positive effect on chronic diseases, coarse cereals exert a vital role in food industry. CC and the main contents prevent tumor pathogenesis through promoting apoptosis, inducing cell cycle arrest as well as modulating metastasis initiation. Meanwhile, CC ameliorates cardiovascular diseases through affecting multiple pathways, such as CaMKII/p-BFAF-3, NF-κB, MAPK, PI3K/Akt, etc. Besides, CC and the main contents have potential as prebiotics which facilitating the activities and growth of probiotics such as Bifidobacteria and Lactobacillus . However, there's a lack of report on CC' beneficial properties and the underlying mechanisms are not fully understood. Here this article explains in detail, the effect and mechanism of CC on chronic diseases like tumor, inflammation and cardiovascular diseases.