Characterization of chemical composition and prebiotic effect of a dietary medicinal plant Penthorum chinense Pursh. (30th July 2020)

• Record Type: Journal Article
• Authors: Yin, Jianhua; Ren, Wei; Wei, Bin; Huang, Huimin; Li, Mingxing; Wu, Xiaoxiao; Wang, Anqi; Xiao, Zhangang; Shen, Jing; Zhao, Yueshui; Du, Fukuan; Ji, Huijiao; Kaboli, Parham Jabbarzadeh; Ma, Yongshun; Zhang, Zhuo; Cho, Chi Hin; Wang, Shengpeng; Wu, Xu; Wang, Yitao
• Is Part Of: Food chemistry. Volume 319(2020)
• Publication Date: 2020-07-30
• Subjects: ALD alcoholic liver disease -- CAT catalase -- ESI electrospray ionization -- GSH glutathione -- GSH-Px glutathione peroxidase -- KEGG Kyoto Encyclopedia of Genes and Genomes -- LDA linear discriminant analysis -- LEfSe linear discriminant analysis effect size -- NALD non-alcoholic liver disease -- NASH non-alcoholic steatohepatitis -- OUT operational taxonomic unit -- PCoA principal co-ordinates analysis -- PLS-DA partial least squares discriminant analysis -- SCFA short-chain fatty acid -- SOD superoxide dismutase -- T-AOC total antioxidant capacity -- UPLC-HR-MS ultra high-performance liquid chromatography coupled with high resolution mass spectrometry; Penthorum chinense -- Mass spectrometry -- Polyphenol -- Gut microbiota -- Prebiotic -- Antioxidant; Quercetin (PubChem CID 5280343) -- Quercetin-3-O-Glucoside (PubChem CID 5280804) -- Quercetin-3-O-Arabinfuranoside (PubChem CID 5481224) -- Quercetin-3-O-Rhamnoside (PubChem CID 5280459) -- Kaempferol (PubChem CID 5280863) -- Kaempferol-3-O-Rutinoside (PubChem CID 5318767) -- Pinocembrin (PubChem CID 68071) -- Thonningianin A (PubChem CID 10328286) -- Gallic Acid (PubChem CID 370) -- Brevifolin Carboxylic Acid (PubChem CID 9838995); Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2020.126568
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Qualitative and quantitative analysis of polyphenols in P. Chinense by UPLC-HR-MS and UHPLC-QqQ-MS. Alteration of composition of gut microbiota by P. Chinense . Enriched gut health-promoting bacteria by P. Chinense with enhanced metabolic resilience, suggesting a prebiotic effect. Significantly increased antioxidant capacity in vivo by P. Chinense . Abstract: Penthorum chinense Pursh is a dietary medicinal plant widely distributed in Asia-Pacific countries. The present study aims to profile the chemical constituents of P. chinense and investigate its prebiotic role in modulating gut microbiota. Fifty polyphenolic compounds were rapidly identified using UPLC-HR-MS. Total flavonoid and phenolic contents of P. chinense were 46.6% and 61.3% ( w/w ), respectively. Thirteen individual polyphenols were quantified, which accounted for 33.1% ( w/w ). P. chinense induced structural arrangement of microbial community in mice, showing increased microbiota diversity, elevated Bacteroidetes / Firmicutes ratio and enriched gut health-promoting bacteria. After a one-week drug-free wash, most of these changes were recovered, but the abundance of some beneficial bacteria was further increased. The altered composition of gut microbiota enriched several metabolic pathways. Moreover, P. chinense increased antioxidant capacity in vivo . The results suggest that polyphenol-enriched P. chinense modulates gut microbiota and enhances antioxidant capacity in mice toward a beneficial environment for host health.