Front Cover: Procyanidin C1 Inhibits Melanoma Cell Growth by Activating 67‐kDa Laminin Receptor Signaling. Issue 7 (14th April 2020)

• Record Type: Journal Article
• Authors: Bae, Jaehoon; Kumazoe, Motofumi; Murata, Kyosuke; Fujimura, Yoshinori; Tachibana, Hirofumi
• Is Part Of: Molecular nutrition & food research. Volume 64:Issue 7(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-04-14
• Subjects: Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.202070017
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Mol. Nutr. Food Res . 2020, 64, 1900986 DOI: 10.1002/mnfr.201900986 In article 1900986, Hirofumi Tachibana and co‐workers identify a 67‐kDa laminin receptor (67LR) as a cell‐surface‐sensing receptor of Procyanidin C1 (PC1), which is found mainly in grape seeds, cacao beans, and apple peels. PC1 shows bioactivity by activating the protein kinase A (PKA)/protein phosphatase 2A (PP2A)/C‐kinase potentiated protein phosphatase‐1 inhibitor protein of 17 kDa (CPI17)/myosin regulatory light‐chain (MRLC)‐pathway through 67LR.