Maternal dietary uridine supplementation reduces diarrhea incidence in piglets by regulating the intestinal mucosal barrier and cytokine profiles. (27th April 2020)
- Record Type:
- Journal Article
- Title:
- Maternal dietary uridine supplementation reduces diarrhea incidence in piglets by regulating the intestinal mucosal barrier and cytokine profiles. (27th April 2020)
- Main Title:
- Maternal dietary uridine supplementation reduces diarrhea incidence in piglets by regulating the intestinal mucosal barrier and cytokine profiles
- Authors:
- Wu, Xin
Gao, Lu‐Min
Liu, Yi‐Lin
Xie, Chunyan
Cai, Lichuang
Xu, Kang
Zhou, Xi‐Hong - Abstract:
- Abstract: BACKGROUND: Nucleotides play an important role in the regulation of cellular energy and protein homeostasis, which facilitate the repair, recovery and repletion of tissue function. This study tested the effects of maternal uridine (UR) supplementation during late pregnancy and lactation of sows on the immune function of the small intestine in neonatal and suckling piglets. RESULTS: Results showed that compared to the control group, maternal dietary UR supplementation significantly decreased incidence of diarrhea in suckling piglets ( P < 0.01); and increased both duodenal and ileal average villus height ( P < 0.01) as well as villus height/crypt depth in ileum ( P = 0.017) in neonatal piglets. RT‐qPCR results showed that maternal UR supplementation decreased mRNA expression of claudin‐1 in jejunum and ileum of neonatal piglets ( P < 0.05), while significantly increased mRNA expression of claudin‐1 in duodenum and jejunum of suckling piglets. Furthermore, in suckling piglets, maternal dietary UR supplementation increased mRNA expression of IL‐6, IL‐8 and IL‐1β in duodenum, jejunum and ileum ( P < 0.05), increased IL‐10 expression in both jejunal and ileal mucosa ( P < 0.05) and increased mRNA expression of IKB and TLR4 in ileal mucosa ( P < 0.05). CONCLUSIONS: These results suggest that maternal dietary supplementation with UR contributed to reducing incidence of diarrhea by regulating cytokine secretion and intestinal mucosal barrier function in sucklingAbstract: BACKGROUND: Nucleotides play an important role in the regulation of cellular energy and protein homeostasis, which facilitate the repair, recovery and repletion of tissue function. This study tested the effects of maternal uridine (UR) supplementation during late pregnancy and lactation of sows on the immune function of the small intestine in neonatal and suckling piglets. RESULTS: Results showed that compared to the control group, maternal dietary UR supplementation significantly decreased incidence of diarrhea in suckling piglets ( P < 0.01); and increased both duodenal and ileal average villus height ( P < 0.01) as well as villus height/crypt depth in ileum ( P = 0.017) in neonatal piglets. RT‐qPCR results showed that maternal UR supplementation decreased mRNA expression of claudin‐1 in jejunum and ileum of neonatal piglets ( P < 0.05), while significantly increased mRNA expression of claudin‐1 in duodenum and jejunum of suckling piglets. Furthermore, in suckling piglets, maternal dietary UR supplementation increased mRNA expression of IL‐6, IL‐8 and IL‐1β in duodenum, jejunum and ileum ( P < 0.05), increased IL‐10 expression in both jejunal and ileal mucosa ( P < 0.05) and increased mRNA expression of IKB and TLR4 in ileal mucosa ( P < 0.05). CONCLUSIONS: These results suggest that maternal dietary supplementation with UR contributed to reducing incidence of diarrhea by regulating cytokine secretion and intestinal mucosal barrier function in suckling piglets. © 2020 Society of Chemical Industry … (more)
- Is Part Of:
- Journal of the science of food and agriculture. Volume 100:Number 9(2020)
- Journal:
- Journal of the science of food and agriculture
- Issue:
- Volume 100:Number 9(2020)
- Issue Display:
- Volume 100, Issue 9 (2020)
- Year:
- 2020
- Volume:
- 100
- Issue:
- 9
- Issue Sort Value:
- 2020-0100-0009-0000
- Page Start:
- 3709
- Page End:
- 3718
- Publication Date:
- 2020-04-27
- Subjects:
- uridine -- intestinal barrier -- cytokines -- pregnant sows -- suckling piglets
Food -- Periodicals
Agriculture -- Periodicals
664 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0010 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/jsfa.10410 ↗
- Languages:
- English
- ISSNs:
- 0022-5142
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5055.000000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 13189.xml