Protein A superantigen: structure, engineering and molecular basis of antibody recognition. Issue 8 (22nd October 2019)

• Record Type: Journal Article
• Authors: Mazigi, Ohan; Schofield, Peter; Langley, David B; Christ, Daniel
• Editors: Bradbury, Andrew
• Is Part Of: Protein engineering, design & selection. Volume 32:Issue 8(2019)
• Page Start: 359
• Page End: 366
• Publication Date: 2019-10-22
• Subjects: antibody -- antibody Fc -- antibody variable domain VH -- protein A -- protein engineering -- SpA -- superantigen; Protein engineering -- Periodicals; 660.63
• DOI: 10.1093/protein/gzz026
• Languages: English
• ISSNs: 1741-0126

Abstract

Abstract: Staphylococcus aureus interacts with the human immune system through the production of secreted factors. Key among these is protein A, a B-cell superantigen capable of interacting with both antibody Fc and VH regions. Here, we review structural and molecular features of this important example of naturally occurring bacterial superantigens, as well as engineered variants and their application in biotechnology.