A metagenomic analysis of the modulatory effect of Cyclocarya paliurus flavonoids on the intestinal microbiome in a high‐fat diet‐induced obesity mouse model. (5th March 2019)

• Record Type: Journal Article
• Authors: Cheng, Lu; Chen, Yuhui; Zhang, Xin; Zheng, Xiaojie; Cao, Jinxuan; Wu, Zufang; Qin, Wenyan; Cheng, Kejun
• Is Part Of: Journal of the science of food and agriculture. Volume 99:Number 8(2019)
• Page Start: 3967
• Page End: 3975
• Publication Date: 2019-03-05
• Subjects: Cyclocarya paliurus flavonoids -- intestinal microbiome -- metagenomics -- modulatory effect -- obesity; Food -- Periodicals; Agriculture -- Periodicals; 664
• DOI: 10.1002/jsfa.9622
• Languages: English
• ISSNs: 0022-5142

Abstract

Abstract: BACKGROUND: As a result of a low bioavailability, the majority of Cyclocarya paliurus flavonoids (CPF) remain in the large intestine where they accumulate to exert a modulatory effect on the intestinal micro‐ecology. Therefore, the present study investigated the modulatory effect of CPF on intestinal microbiota. RESULTS: CPF dramatically ameliorated the obesity‐induced gut dysbiosis. A significant decrease ( P < 0.05) was observed in the ratio of Firmicutes / Bacteroidetes after CPF treatment for 8 weeks. Moreover, Kyoto Encyclopedia of Genes and Genomes pathways of biosynthesis of amino acids, the two‐component system and ATP‐binding cassette transporters enriched the most differentially expressed genes after CPF intervention. CONCLUSION: The results of the present study indicate that CPF might have prebiotic‐like activity and could be used as a functional food component with potential therapeutic utility to prevent obesity‐related metabolic disorders by manipulating the gut flora and affecting certain metabolic pathways, thus contributing to the improvement of human health. © 2019 Society of Chemical Industry