Polymorphism −765G>C in Cyclooxygenase-2 and Risk of Colorectal Cancer. Issue 2 (26th October 2015)

• Record Type: Journal Article
• Authors: Khorshidi, Fatemeh; Mohebbi, Seyed Reza; Haghighi, Mahdi Montazer; Taleghani, Mohammad Yaghoob; Azimzadeh, Pedram; Golmohammadi, Mina; Alidadi, Maede; Romani, Sara; Vahedi, Mohsen; Mojarad, Ehsan Nazemalhosseini; Zali, Mohammad Reza
• Is Part Of: Laboratory medicine. Volume 44:Issue 2(2013)
• Page Start: e14
• Page End: e18
• Publication Date: 2015-10-26
• Subjects: Cyclooxygenase-2 (COX-2) -- Single nucleotide polymorphism (SNP) -- colorectal cancer (CRC). RFLP -- restriction fragment length polymorphism -- rs20417 -- Polymerase chain reaction (PCR); Clinical chemistry -- Periodicals; Pathology -- Periodicals; Medical technology -- Periodicals; Chemistry, Clinical; Pathology; Medical Laboratory Science; Clinical chemistry; Medical technology; Pathology; Electronic journals; Periodicals; Periodicals; 616
• DOI: 10.1309/LMVAX2QHHIBWY1H7
• Languages: English
• ISSNs: 0007-5027

Abstract

Abstract : Colorectal cancer is the third-most-prevalent form of cancer in the world. Several studies report that prostaglandins are mediators of carcinogenesis. Cyclooxygenase, also known as prostaglandin endoperoxidase H synthase, is a pro-inflammatory enzyme that intercedes in the formation of eicosanoids from arachidonic acid. Polymorphisms in the COX-2 gene have been associated with increased risk of different tumors, including colorectal. Genetic variations in COX-2 may affect enzyme activity or expression, thereby altering the production of prostaglandins and potentially modulating an individual's inflammatory response and risk of colorectal cancer. A functional polymorphism in the COX-2 promoter region (−765G>C), located at a putative stimulatory protein-1 (SP1) binding site, suggests the involvement of a complex array of factors regulating its expression. This study was designed to evaluate the status of −765G>C polymorphism (rs20417) and risk of sporadic colorectal cancer in an Iranian population.