Polymorphism −765G>C in Cyclooxygenase-2 and Risk of Colorectal Cancer. Issue 2 (26th October 2015) - Khorshidi, Fatemeh
Abstract : Colorectal cancer is the third-most-prevalent form of cancer in the world. Several studies report that prostaglandins are mediators of carcinogenesis. Cyclooxygenase, also known as prostaglandin endoperoxidase H synthase, is a pro-inflammatory enzyme that intercedes in the formation of eicosanoids from arachidonic acid. Polymorphisms in the COX-2 gene have been associated with increased risk of different tumors, including colorectal. Genetic variations in COX-2 may affect enzyme activity or expression, thereby altering the production of prostaglandins and potentially modulating an individual's inflammatory response and risk of colorectal cancer. A functional polymorphism in the COX-2 promoter region (−765G>C), located at a putative stimulatory protein-1 (SP1) binding site, suggests the involvement of a complex array of factors regulating its expression. This study was designed to evaluate the status of −765G>C polymorphism (rs20417) and risk of sporadic colorectal cancer in an Iranian population.