A general method for site-selective Csp3–S bond formation via cooperative catalysis. Issue 5 (19th December 2019)

• Record Type: Journal Article
• Authors: Qin, Yuman; Han, Yujie; Tang, Yongzhen; Wei, Junfa; Yang, Mingyu
• Is Part Of: Chemical science. Volume 11:Issue 5(2020)
• Page Start: 1276
• Page End: 1282
• Publication Date: 2019-12-19
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9sc04169a
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : A copper-catalyzed site-selective thiolation of Csp 3 –H bonds of aliphatic amines was developed. The method features a broad substrate scope and good functional group tolerance. Abstract : Herein, we report a copper-catalysed site-selective thiolation of Csp 3 –H bonds of aliphatic amines. The method features a broad substrate scope and good functional group compatibility. Primary, secondary, and tertiary C–H bonds can be converted into C–S bonds with a high efficiency. The late-stage modification of biologically active compounds by this method was also demonstrated. Furthermore, the one-pot preparation of pyrrolidine or piperidine compounds via a domino process was achieved.