A general method for site-selective Csp3–S bond formation via cooperative catalysis. Issue 5 (19th December 2019) - Qin, Yuman
Abstract : A copper-catalyzed site-selective thiolation of Csp 3 –H bonds of aliphatic amines was developed. The method features a broad substrate scope and good functional group tolerance. Abstract : Herein, we report a copper-catalysed site-selective thiolation of Csp 3 –H bonds of aliphatic amines. The method features a broad substrate scope and good functional group compatibility. Primary, secondary, and tertiary C–H bonds can be converted into C–S bonds with a high efficiency. The late-stage modification of biologically active compounds by this method was also demonstrated. Furthermore, the one-pot preparation of pyrrolidine or piperidine compounds via a domino process was achieved.