Direct arylation of C60Cl6 and C70Cl8 with carboxylic acids: a synthetic avenue to water-soluble fullerene derivatives with promising antiviral activity. Issue 8 (23rd December 2019)

• Record Type: Journal Article
• Authors: Kraevaya, Olga A.; Peregudov, Alexander S.; Godovikov, Ivan A.; Shchurik, Elena V.; Martynenko, Vyacheslav M.; Shestakov, Alexander F.; Balzarini, Jan; Schols, Dominique; Troshin, Pavel A.
• Is Part Of: Chemical communications. Volume 56:Issue 8(2020)
• Page Start: 1179
• Page End: 1182
• Publication Date: 2019-12-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc08400b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Unprecedented Friedel–Crafts arylation of chlorofullerenes C60 Cl6 and C70 Cl8 with unprotected carboxylic acids has been utilized for efficient single-step synthesis of the inherently stable water-soluble fullerene derivatives. Abstract : We report unprecedented Friedel–Crafts arylation of chlorofullerenes C60 Cl6 and C70 Cl8 with unprotected carboxylic acids as an efficient single-step synthesis of the inherently stable water-soluble fullerene derivatives. Using this method, a series of previously unaccessible compounds was obtained without chromatographic purification in almost quantitative yields. Promising anti-HIV activity comparable to characteristics of commercial drugs was demonstrated for some of these compounds.