Direct arylation of C60Cl6 and C70Cl8 with carboxylic acids: a synthetic avenue to water-soluble fullerene derivatives with promising antiviral activity. Issue 8 (23rd December 2019) - Kraevaya, Olga A.
Abstract : Unprecedented Friedel–Crafts arylation of chlorofullerenes C60 Cl6 and C70 Cl8 with unprotected carboxylic acids has been utilized for efficient single-step synthesis of the inherently stable water-soluble fullerene derivatives. Abstract : We report unprecedented Friedel–Crafts arylation of chlorofullerenes C60 Cl6 and C70 Cl8 with unprotected carboxylic acids as an efficient single-step synthesis of the inherently stable water-soluble fullerene derivatives. Using this method, a series of previously unaccessible compounds was obtained without chromatographic purification in almost quantitative yields. Promising anti-HIV activity comparable to characteristics of commercial drugs was demonstrated for some of these compounds.