1α, 25(Oh)2Vitamin D3-Regulated Expression of the Eukaryotic Genome. (8th October 2014)

• Record Type: Journal Article
• Authors: Hannah, Steven S.; Norman, Anthony W.
• Is Part Of: Nutrition reviews. Volume 52:Number 11(1994)
• Page Start: 376
• Page End: 382
• Publication Date: 2014-10-08
• Subjects: Nutrition -- Periodicals; Diet -- Periodicals; Diet -- Periodicals; Nutrition -- Periodicals; Voeding; 613.2
• DOI: 10.1111/j.1753-4887.1994.tb01368.x
• Languages: English
• ISSNs: 0029-6643

Abstract

Abstract : 1α, 25(OH)2 vitamin-D3, [1α, 25(OH)2 D3 ] is a potent steroid hormone that produces a wide array of biologic effects in a variety of target tissues within the body through its ability to modulate gene transcription of specific target genes. Evidence for transcription regulation of a specific gene typically includes 1α, 25(OH)2 D3 -induced modulation in mRNA levels. Additionally, evidence may include measurements of transcription and or the presence of a vitamin D response element within the promoter region of the gene. To date, over 50 genes have been reported to be transcriptionally regulated by 1α, 25(OH)2 D3 - We present a current list of these genes and the evidence supporting their inclusion on the list.