Study of anticancer, antimicrobial, immunomodulatory, and silver nanoparticles production by Sidr honey from three different sources. Issue 1 (9th December 2019)

• Record Type: Journal Article
• Authors: Ghramh, Hamed A.; Ibrahim, Essam H.; Kilany, Mona
• Is Part Of: Food science & nutrition. Volume 8:Issue 1(2020)
• Page Start: 445
• Page End: 455
• Publication Date: 2019-12-09
• Subjects: AgNPs -- anticancer -- antimicrobial -- Apis mellifera -- Sidr honey -- splenic cells; Food industry and trade -- Periodicals; Food -- Periodicals; Nutrition -- Periodicals; 664
• DOI: 10.1002/fsn3.1328
• Languages: English
• ISSNs: 2048-7177

Abstract

Abstract: Sidr honey is used as food and medicine in many countries. Study of immunomodulatory and anticancer activity of Sidr honey did not tested before. The aim of this work was to study the anticancer activity and immunomodulatory as well as antimicrobial potential of Sidr honey and its synthesized silver nanoparticles (AgNPs). Sidr honey from three sources (two from Kingdom of Saudi Arabia (KSA) and one from Pakistan) was diluted to 20% and tested for its biological activities and to synthesize AgNPs. The results demonstrated that honeys could produce AgNPs (spherical shape), modulated the growth of normal splenic cells, and have antimicrobial activities. Sidr honey has anticancer activity against HepG2 but not Hela cells. Sidr honey can be used as antimicrobial agent, but can be used as anticancer agent with care as it stimulated cell growth of some lines (e.g., Hala) and inhibited another (e.g., HepG2). Abstract : Sidr honey is used as food and medicine in many countries. Sidr honey from three sources (two from Kingdom of Saudi Arabia (KSA) and one from Pakistan) was examined. The results demonstrated that honeys could produce AgNPs, modulated the growth of normal splenic cells, have antimicrobial activities and anticancer activity against HepG2 but not Hela cells.