A Systematic Review and Meta-analysis of Randomized Controlled Trials on the Effects of Turmeric and Curcuminoids on Blood Lipids in Adults with Metabolic Diseases. Issue 5 (18th June 2019)

• Record Type: Journal Article
• Authors: Yuan, Fen; Dong, Hui; Gong, Jing; Wang, Dingkun; Hu, Meilin; Huang, Wenya; Fang, Ke; Qin, Xin; Qiu, Xin; Yang, Xueping; Lu, Fuer
• Is Part Of: Advances in nutrition. Volume 10:Issue 5(2019)
• Page Start: 791
• Page End: 802
• Publication Date: 2019-06-18
• Subjects: turmeric -- curcuminoids -- triglyceride -- total cholesterol -- LDL cholesterol -- HDL cholesterol -- lipids; Nutrition -- Periodicals; Diet therapy -- Periodicals; Nutrition; Nutritional Physiological Phenomena; Nutritional Sciences; Periodicals; 613.205
• DOI: 10.1093/advances/nmz021
• Languages: English
• ISSNs: 2161-8313

Abstract

ABSTRACT: Dyslipidemia is a global health problem and a high risk factor for atherosclerosis, which can lead to serious cardiovascular disease (CVD). Existing studies have shown inconsistent effects of turmeric and curcuminoids on blood lipids in adults. We performed this systematic review and meta-analysis to evaluate the effects of turmeric and curcuminoids on blood triglycerides (TG), total cholesterol (TC), LDL cholesterol, and HDL cholesterol. We searched the English databases of the Web of Science, PubMed, Ovid (including EMBASE and MEDLINE), Scopus, and the Cochrane Library and 2 Chinese databases, Wanfang Data and China National Knowledge Infrastructure, for randomized controlled trials (RCTs) that studied the effects of turmeric and curcuminoids on blood TG, TC, LDL cholesterol, and HDL cholesterol in subjects with metabolic diseases. With random-effects models, separate meta-analyses were conducted by using inverse-variance. The results are presented as the mean difference with 95% CIs. Evidence from 12 RCTs for TG, 14 RCTs for TC, 13 RCTs for LDL cholesterol, and 16 RCTs for HDL cholesterol showed that turmeric and curcuminoids could lower blood TG by −19.1 mg/dL (95% CI: −31.7, −6.46 mg/dL; P = 0.003), TC by −11.4 mg/dL (95% CI: −17.1, −5.74 mg/dL; P < 0.0001), and LDL cholesterol by −9.83 mg/dL (95% CI: −15.9, −3.74 mg/dL; P = 0.002), and increase HDL cholesterol by 1.9 mg/dL (95% CI: 0.31, 3.49 mg/dL; P = 0.02). In conclusion, turmeric and curcuminoids can significantly modulate blood lipids in adults with metabolic diseases. However, these findings should be interpreted cautiously because of the significant heterogeneity between included studies ( I 2 > 50%). There is a need for further RCTs in future.