The Effect of an Iron Supplement on Lycopene Metabolism and Absorption During Digestion in Healthy Humans. Issue 22 (6th September 2019)

• Record Type: Journal Article
• Authors: Kopec, Rachel E.; Caris‐Veyrat, Catherine; Nowicki, Marion; Bernard, Jean‐Paul; Morange, Sophie; Chitchumroonchokchai, Chureeporn; Gleize, Béatrice; Borel, Patrick
• Is Part Of: Molecular nutrition & food research. Volume 63:Issue 22(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-09-06
• Subjects: apo‐lycopenals/apo‐lycopenoids -- bioavailability -- carotenoids -- ferrous sulfate -- gastrointestinal lumen; Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201900644
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Scope: To investigate the formation and absorption of lycopene (LYC) metabolites in the human upper gastrointestinal lumen, in the absence and presence of iron. Methods: Healthy males ( n = 7) consumed test meals that deliver ≈22 mg LYC + ≈0.3 mg apo‐lycopenals from oleoresin without (‐FeSO4 ) and with ferrous sulfate (160 mg, +FeSO4 ). Subjects were intubated with a naso‐gastric/naso‐duodenal tube. Digesta, blood plasma, and the triglyceride‐rich lipoprotein (TRL) fractions of plasma were analyzed using LC–MS/MS, to measure LYC and apo‐lycopenoids. Results: Digesta LYC concentrations increased with time ( p = 1.2 × 10 −7 ), decrease with time × iron ( p = 1.1 × 10 −5 ), and remain ≈200× higher than apo‐lycopenals/lycopenone. Digesta apo‐8′‐, ‐10′‐, ‐12′‐, ‐14′‐, ‐15‐lycopenal, and apo‐13‐lycopenone concentrations increased with time ( p < 0.01), apo‐12′‐, ‐14′‐, ‐15‐lycopenal, apo‐13‐lycopenone increase with iron ( p < 0.05), and time × iron decrease apo‐8′‐, ‐10′‐, ‐12′‐, ‐14′‐, ‐15‐lycopenal, apo‐13‐lycopenone concentrations ( p < 0.01). A 1.9‐fold decrease in LYC TRL area‐under‐the‐time‐concentration‐curve is observed after the test meal +FeSO4 versus the test meal –FeSO4 ( p = 0.02). Apo‐lycopenals were detected in later TRL fractions, and no apo‐lycopenols or apo‐lycopenoic acids were observed in any samples. Conclusions: FeSO4 reduces LYC absorption. Apo‐lycopenals appear to be absorbed from foods, and not made in significant quantities during digestion. Abstract : The role of supplemental iron (FeSO4 ) on lycopene absorption and apo‐lycopenal metabolite formation is investigated. Subjects were fed a lycopene meal alone, or a lycopene meal + iron, and samples taken from the stomach, duodenum, and blood plasma. Iron reduced digesta concentrations of lycopene and reduced lycopene bioavailability by ≈2×, as compared to the lycopene meal alone. Apo‐lycopenal concentrations remained low relative to lycopene in the digesta.