Two new sesquiterpene pyridine alkaloids from root barks of Celastrus angulatus. Issue 11 (2nd November 2019)

• Record Type: Journal Article
• Authors: Chang, Xia; Wang, Zhi-Yao; Chen, Xin; Ma, Yan-Ni; Zhang, Hai-Yan; Zhao, Tian-Zeng
• Is Part Of: Journal of Asian natural products research. Volume 21:Issue 11(2019)
• Page Start: 1043
• Page End: 1051
• Publication Date: 2019-11-02
• Subjects: Celastraceae -- Celastrus angulatus -- sesquiterpene pyridine alkaloids -- Chinese bittersweet alkaloid A -- Chinese bittersweet alkaloid B -- NMR; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1492563
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new sesquiterpene pyridine alkaloids, Chinese bittersweet alkaloid A (1 ) and Chinese bittersweet alkaloid B (2 ), together with five known compounds 3β- hydroxyolean-9(11), 12-diene, β-sitosterol, 1β, 2β, 6α, 15β-tetraacetoxy-8β, 9α- dibenzoyloxy-β-dihydroagarofuran, angulatin A and angulatin J, were isolated from the root barks of Celastrus angulatus . The structures of 1 and 2 were elucidated as 1β, 6α, 8β, 9β-tetraacetoxy-2β, 4α-dihydroxy-15β-isobutanoyloxy-(3, 12)-evoninoyloxy-β-dihydroagarofuran and 1β, 2β, 6α, 8β, 9β-pentaacetoxy-4α-hydroxy-15β- isobutanoyloxy- (3, 12)- evoninoyloxy-β-dihydroagarofuran mainly by NMR spectroscopic means. Graphical Abstract: