Two new sesquiterpene pyridine alkaloids from root barks of Celastrus angulatus. Issue 11 (2nd November 2019) - Chang, Xia
Abstract: Two new sesquiterpene pyridine alkaloids, Chinese bittersweet alkaloid A (1 ) and Chinese bittersweet alkaloid B (2 ), together with five known compounds 3β- hydroxyolean-9(11), 12-diene, β-sitosterol, 1β, 2β, 6α, 15β-tetraacetoxy-8β, 9α- dibenzoyloxy-β-dihydroagarofuran, angulatin A and angulatin J, were isolated from the root barks of Celastrus angulatus . The structures of 1 and 2 were elucidated as 1β, 6α, 8β, 9β-tetraacetoxy-2β, 4α-dihydroxy-15β-isobutanoyloxy-(3, 12)-evoninoyloxy-β-dihydroagarofuran and 1β, 2β, 6α, 8β, 9β-pentaacetoxy-4α-hydroxy-15β- isobutanoyloxy- (3, 12)- evoninoyloxy-β-dihydroagarofuran mainly by NMR spectroscopic means. Graphical Abstract: