Isoflavones enhance the plasma cholesterol-lowering activity of 7S protein in hypercholesterolemic hamsters. Issue 11 (25th October 2019)

• Record Type: Journal Article
• Authors: Liu, Yuwei; Yang, Juan; Lei, Lin; Wang, Lijun; Wang, Xiaobo; Ma, Ka Ying; Yang, Xiaoquan; Chen, Zhen-Yu
• Is Part Of: Food & function. Volume 10:Issue 11(2019)
• Page Start: 7378
• Page End: 7386
• Publication Date: 2019-10-25
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/c9fo01432b
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : Effect of isoflavones and soybean 7S protein on plasma cholesterol. Abstract : Previous studies have shown that 7S protein is the active ingredient responsible for the plasma cholesterol-lowering activity of soybean. It is hypothesized that isoflavones in soybean could enhance the blood cholesterol-lowering activity of 7S protein. Forty-eight hamsters were divided into six groups and fed a non-cholesterol diet or one of the five high-cholesterol diets containing 12.1% 7S protein with 0–15.62 mg g −1 isoflavones. The results showed that addition of isoflavones in diets dose-dependently enhanced the plasma total cholesterol-lowering activity of 7S protein. Addition of isoflavones in 7S protein-based diets significantly reduced hepatic cholesterol accumulation by 12.6–26.1%, compared with the high cholesterol control diet. Isoflavones could also facilitate excretion of neutral sterols in a dose-dependent manner. Supplementation of isoflavones in diets favourably modulated mRNA expression and the protein mass of HMG-CoA reductase. It was concluded that the enhancing effect of isoflavones on the blood cholesterol-lowering activity of 7S protein was mediated by inhibiting the cholesterol absorption and de novo cholesterol synthesis in hypercholesterolemic hamsters.