Protective effects of hydroalcoholic extracts from an ancient apple variety 'Mela Rosa dei Monti Sibillini' against renal ischemia/reperfusion injury in rats. Issue 11 (5th November 2019)

• Record Type: Journal Article
• Authors: Yousefi-Manesh, Hasan; Hemmati, Sara; Shirooie, Samira; Nabavi, Seyed Mohammad; Talebzadeh Bonakdar, Azita; Fayaznia, Reza; Hossein Asgardoon, Mohammad; Zare Dehnavi, Ali; Ghafouri, Mohammad; Nkuimi Wandjou, Joice G.; Caprioli, Giovanni; Sut, Stefania; Maggi, Filippo; Dall'Acqua, Stefano
• Is Part Of: Food & function. Volume 10:Issue 11(2019)
• Page Start: 7544
• Page End: 7552
• Publication Date: 2019-11-05
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/c9fo01635j
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : The purpose of this work was to investigate the effect of hydroalcoholic extracts from the peel and pulp of a traditional apple variety of central Italy on the damage caused by renal ischemia/reperfusion injury in rats. Abstract : The purpose of this work was to investigate the effect of hydroalcoholic extracts from the peel (APE) and pulp (APP) of a traditional apple variety of central Italy, the 'Mela Rosa dei Monti Sibillini', on the damage caused by renal ischemia/reperfusion injury (IRI) in rats. Thirty mg per kg b.w. of the extracts were administered intraperitoneally to male adult Wistar rats 3 days before the induction of IRI by pedicle clamping. A significant decrease in the levels of malondialdehyde (MDA), tumor necrosis factor-α (TNFα), interleukin 1 beta (IL-1β) and nuclear factor-κB (NF-κB) was observed in the groups pre-treated with APE when compared with IRI rats. The chemical composition of APE was determined by HPLC-DAD-MS n highlighting a significant amount of proanthocyanidins (52.9 mg g −1 ), flavonols (42.27 mg g −1 ) and dihydrochalcones (11.75 mg g −1 ). These findings indicated that this ancient apple variety is a promising source of nutraceuticals and functional foods helpful to manage complications of renal disorders.