Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies. Issue 4 (15th April 2019)

• Record Type: Journal Article
• Authors: Fretts, Amanda M; Imamura, Fumiaki; Marklund, Matti; Micha, Renata; Wu, Jason H Y; Murphy, Rachel A; Chien, Kuo-Liong; McKnight, Barbara; Tintle, Nathan; Forouhi, Nita G; Qureshi, Waqas T; Virtanen, Jyrki K; Wong, Kerry; Wood, Alexis C; Lankinen, Maria; Rajaobelina, Kalina; Harris, Tamara B; Djoussé, Luc; Harris, Bill; Wareham, Nick J; Steffen, Lyn M; Laakso, Markku; Veenstra, Jenna; Samieri, Cécilia; Brouwer, Ingeborg A; Yu, Chaoyu Ian; Koulman, Albert; Steffen, Brian T; Helmer, Catherine; Sotoodehnia, Nona; Siscovick, David; Gudnason, Vilmundur; Wagenknecht, Lynne; Voutilainen, Sari; Tsai, Michael Y; Uusitupa, Matti; Kalsbeek, Anya; Berr, Claudine; Mozaffarian, Dariush; Lemaitre, Rozenn N;
• Is Part Of: American journal of clinical nutrition. Volume 109:Issue 4(2019)
• Page Start: 1216
• Page End: 1223
• Publication Date: 2019-04-15
• Subjects: saturated fatty acids -- very-long-chain saturated fatty acids -- diabetes -- meta-analysis -- Fatty Acids and Outcomes Research Consortium -- Cohorts for Heart and Aging Research in Genomic Epidemiology; Diet therapy -- Periodicals; Nutrition -- Periodicals; Dietetics -- Periodicals; 613.205
• DOI: 10.1093/ajcn/nqz005
• Languages: English
• ISSNs: 0002-9165

Abstract

ABSTRACT: Background: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. Objective: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. Methods: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51, 431 participants. Results: There were 14, 276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95% CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. Conclusions: Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.